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Medical Animation

Medical Animation: The Gene Doctors

Created for Tangled Bank Studios, HHMI

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The Gene Doctors title page. Base pair highlighted in a strand of DNA floating in the nucleus. © 2017 Tangled Tangled Bank Studios, LLC. All rights reserved.

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Mucosal lining of lung, depicting cilia on epithelial cell. © 2017 Tangled Tangled Bank Studios, LLC. All rights reserved.

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Cell cytoplasm scene from The Gene Doctors © 2017 Tangled Tangled Bank Studios, LLC. All rights reserved.

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Adeno-associated virus (AAV) gene therapy. View from inside syringe. © 2017 Tangled Tangled Bank Studios, LLC. All rights reserved.

The project

A feature-length documentary about inherited diseases. Diverse storytelling needs called for 2 medical animation styles: 1) 3D visualization for immersive journeys; 2) Hand-drawn for concepts and processes. The resulting visualizations showcase incredible molecular processes for a lay audience and allow both fleeting molecular interactions and long experimental workflows to be memorably communicated.

Created for
Tangled Bank Studios, HHMI

More

Medical Animation

Title screen from XL309 MOA animation. SL is an emerging strategy for targeting cancer cells. Our client’s lead SL candidate, XL309, inhibits USP1, a deubiquitinase essential for single-strand DNA break repair. Due to compensatory DNA repair mechanisms, XL309 has no effect on healthy cells. However, XL309 is lethal in cancers with homologous recombination (HR)-deficiency that have genetic alterations impairing double-strand DNA break repair. To explain this complex story to multiple audiences, we created a clear, concise MOA animation. Flowchart-like 3D motion graphics make it easy to follow the complex interplay of DNA damage repair mechanisms, while molecular scenes illustrate how the different proteins interact to orchestrate DNA repair.

Synthetic lethality (SL) Mechanism of Action (MOA) Animation

Exelixis, Inc.

Still image of ZORYVE (roflumilast) cream on a skin cube from a plaque psoriasis drug MOA animation.

Plaque Psoriasis Drug MOA Animation

Arcutis Biotherapeutics

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Medical Animation: Cancer ADC MOA

Exelixis, Inc.

Still image of the CMB complex from a cancer pathway MOD/MOA animation.

Medical Animation: Cancer Small Molecule MOA

Exelixis, Inc.

Still image from the Certepetide MOA animation showing a solid tumor growing.

Scientific Animation: Certepetide MOA

Lisata Therapeutics

Title slide from zanzalintinib (XL092) mechanism of action (MOA) animation. XL092 is a small-molecule inhibitor of multiple receptor tyrosine kinases (RTKs) that are involved in cancer growth and immune regulation. Animation is divided into chapters. A web-based interactive version of the video was developed for use at congresses. Animation launched at AACR 2022.

Oncology MOD and MOA Animation

Exelixis, Inc

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Scientific Animation - Photobiomodulation Therapy for AMD

LumiThera, Inc.

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Heart Failure MOD Animation

Biopharmaceutical client

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Medical Animation: The Science of Hepatalin

Scimar Ltd.

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Alzheimer's Disease Medical Animation

Banner Health

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Medical Animation: BRAF Inhibitor for Melanoma

Biopharmaceutical client

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Multiple Myeloma Conference Exhibit

Biopharmaceutical Client