The Role of CGRP in Migraine
Created for Biopharmaceutical Client
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Locations in the brain (meningeal arteries, TNC, and trigeminal ganglion) where CGRP binds to CGRP receptors during a mirgaine. © 2017. All Rights Reserved.
Profile view of a female patient with brain anatomy overlayed, defining the cortex, thalamus, trigeminal nerve fibers, trgeminal nucleus caudalis (TNC) and trigeminal ganglion. © 2017. All Rights Reserved.
Synaptic cleft showing the release of CGRP from the presynaptic cleft to the postsynaptic cleft where the CGRP receptors are located. © 2017. All Rights Reserved.
Profile view of a female patient with brain anatomy overlayed (nerve and vascular network) © 2017. All Rights Reserved.
The project
This animation begins with the burden of disease of migraine, moves through pathophysiology, then dives into the story of a key molecular player: CGRP. We depict the localization of CGRP and its receptor in the CNS and peripheral structures and show receptor binding on a molecular level, within a synaptic cleft. A thorough review of the migraine literature informed the script and visuals.
Created for
Biopharmaceutical client
