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Scientific Animation

Scientific Animation: Nanoparticles in Cancer | AXS Studio

Created for Integrated Nanotechnology and Biomedical Sciences Laboratory

Still image from scientific animation about the Nanoparticle Active Transport and Retention (ATR) principle. The silhouetted adult male figure shows the lymphatic and circulatory systems. The nanoparticles can be seen accumulated in the spleen, heart, kidneys and liver.

A short segment of a liver sinusoid viewed from outside of the vessel. The endothelial cells that make up the vessel wall have holes of irregular shape and size, making the inside of the vessel partially visible. Liver cells (hepatocytes) and star-shaped stellate cells flank the vessel. Gold nanoparticles have leaked through the holes in the vessel and into the surrounding liver tissue.

Still image from scientific animation about the Nanoparticle Active Transport and Retention (ATR) principle. A tumour microenvironment is shown. Nanoparticles can be seen exiting blood vessels through a few nanoparticle transport endothelial cells (N-TECs). Fibroblasts and tumour-associated macrophages are also visible, along with a lymphatic vessel in the background.

The project

Nanoparticles (NPs) are an effective way to deliver therapeutic and diagnostic agents to tumors. A full understanding of NP dynamics within the body is key to optimize NP design for clinical use. We created this dynamic 3D scientific animation to take viewers on the incredible journey of NPs, focusing on the active transport and retention principle that governs delivery to solid tumors. Scientific accuracy was of key importance. We consulted our client’s extensive research data, including still and time-lapse micrographs, to accurately visualize the cellular and acellular mechanisms that govern NP tumor entry, retention, and exit. This animation won the 2025 Award of Excellence in didactic/instructional – non-commercial animation from the Association of Medical Illustrators.

Created for
Integrated Nanotechnology and Biomedical Sciences Laboratory

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Scientific Animation

Still image from scientific animation about the Nanoparticle Active Transport and Retention (ATR) principle. The silhouetted adult male figure shows the lymphatic and circulatory systems. The nanoparticles can be seen accumulated in the spleen, heart, kidneys and liver.

Scientific Animation: Nanoparticles in Cancer | AXS Studio

Integrated Nanotechnology and Biomedical Sciences Laboratory

Title screen from XL309 MOA animation. SL is an emerging strategy for targeting cancer cells. Our client’s lead SL candidate, XL309, inhibits USP1, a deubiquitinase essential for single-strand DNA break repair. Due to compensatory DNA repair mechanisms, XL309 has no effect on healthy cells. However, XL309 is lethal in cancers with homologous recombination (HR)-deficiency that have genetic alterations impairing double-strand DNA break repair. To explain this complex story to multiple audiences, we created a clear, concise MOA animation. Flowchart-like 3D motion graphics make it easy to follow the complex interplay of DNA damage repair mechanisms, while molecular scenes illustrate how the different proteins interact to orchestrate DNA repair.

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