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Mechanism Of Action (MOA) Animation

Medical Animation: Redemplo siRNA Mechanism of Action (MOA)

Created for Arrowhead Pharmaceuticals
Still frame from the mechanism of action (MOA) animaton about the small interfering RNA (siRNA), Redemplo (plozasiran). The Redemplo guide strand is bound to RNA-induced silencing compound (RISC) and APOC3 mRNA. The name Redemplo is onscreen along with a closed caption line from the voiceover and molecule labels.
Still frame from the mechanism of action (MOA) animaton about the small interfering RNA (siRNA), Redemplo (plozasiran). We see the outside of an hepatocyte membrane with embedded hepatocyte receptors (ASPGR). Redemplo with its GalNac targeting ligand is bound an ASPGR. The name Redemplo is onscreen along with a closed caption line from the voiceover and molecule labels.
Still frame from the mechanism of action (MOA) animaton about the small interfering RNA (siRNA), Redemplo (plozasiran). This a split screen shot. On the left, Redemplo guide strand, bound to RNA-induced silencing compound (RISC) has separated from APOC3 mRNA after degrading it. On the right is a close of a large orange chylomicron, with prominent APOC3 proteins. The name Redemplo is onscreen along with a closed caption line from the voiceover and an APOC3 label.
Still frame from the mechanism of action (MOA) animaton about the small interfering RNA (siRNA), Redemplo (plozasiran). Red blood cells are seen flowing through a capillary, sectioned longitudinally. Chylomicrons are visualized as small, sparse orange particles. The name Redemplo and labels
The project

Familial chylomicronemia syndrome (FCS) is a rare form of severe hypertriglyceridemia marked by accumulation of chylomicrons in the bloodstream. Redemplo (plozasiran) is a small interfering RNA (siRNA) that lowers triglyceride levels in patients with FCS by silencing apolipoprotein C-III (APOC3), a regulator of chylomicron metabolism. We created a concise video for HCPs, explaining the Redemplo MOA to support commercial launch. A key challenge was explaining how destruction of APOC3 mRNA in the liver translates to reduced triglyceride levels in the bloodstream. We addressed this by a) visually associating APOC3 mRNA with APOC3 proteins, which decrease in number following mRNA degradation, and b) showing a timelapse reduction of chylomicrons in the blood stream. We consulted multiple peer-reviewed references to write the voiceover script and create the scientifically accurate visuals.

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Mechanism Of Action (MOA) Animation

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