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Mechanism Of Action (MOA) Animation

Medical Animation: Cancer Immunotherapy MOA

Created for Biopharmaceutical client

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Cytotoxic T cells attacking malignant tumor cells, resulting in apoptosis. © 2018. All rights reserved.

axs-studio-medical-animation-oncology-immunotherapy-signalling-pathway-scaled

Light torch metaphor of cell signaling for targetted immunotherapy. © 2018. All rights reserved.

axs-studio-medical-animation-oncology-immunotherapy-listeria-bacterium

Listeria-based immunotherapy. © 2018. All rights reserved.

axs-studio-medical-animation-oncology-immunotherapy-trojan

The Tojan horse was employed as a metaphor for cancer immunotherapy that slips into cancer cells to attack from within, limiting damage to healthy tissue. © 2018. All rights reserved.

The project

While there is no “one size fits all” treatment for cancer, as the number of immunotherapies increases, so does the potential for investigating different combination therapies. Here, we used different visual metaphors in order to illuminate the various immunotherapies available, such as a trojan horse for an antibody-drug conjugate. This medical animation was designed to be an eye-catching attraction at oncology congresses, and was developed in high res 6K video for display on super-wide screens.

Created for
Biopharmaceutical client

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Mechanism Of Action (MOA) Animation

Title screen from XL309 MOA animation. SL is an emerging strategy for targeting cancer cells. Our client’s lead SL candidate, XL309, inhibits USP1, a deubiquitinase essential for single-strand DNA break repair. Due to compensatory DNA repair mechanisms, XL309 has no effect on healthy cells. However, XL309 is lethal in cancers with homologous recombination (HR)-deficiency that have genetic alterations impairing double-strand DNA break repair. To explain this complex story to multiple audiences, we created a clear, concise MOA animation. Flowchart-like 3D motion graphics make it easy to follow the complex interplay of DNA damage repair mechanisms, while molecular scenes illustrate how the different proteins interact to orchestrate DNA repair.

Synthetic lethality (SL) Mechanism of Action (MOA) Animation

Exelixis, Inc.

Still image of ZORYVE (roflumilast) cream on a skin cube from a plaque psoriasis drug MOA animation.

Plaque Psoriasis Drug MOA Animation

Arcutis Biotherapeutics

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Medical Animation: Cancer ADC MOA

Exelixis, Inc.

Still image of the CMB complex from a cancer pathway MOD/MOA animation.

Medical Animation: Cancer Small Molecule MOA

Exelixis, Inc.

Still image from the Certepetide MOA animation showing a solid tumor growing.

Scientific Animation: Certepetide MOA

Lisata Therapeutics

Title slide from zanzalintinib (XL092) mechanism of action (MOA) animation. XL092 is a small-molecule inhibitor of multiple receptor tyrosine kinases (RTKs) that are involved in cancer growth and immune regulation. Animation is divided into chapters. A web-based interactive version of the video was developed for use at congresses. Animation launched at AACR 2022.

Oncology MOD and MOA Animation

Exelixis, Inc

axs-studio-medical-animation-melanoma-BRAF-MOA-01b

Medical Animation: BRAF Inhibitor for Melanoma

Biopharmaceutical client

axs-studio-medical-animation-hodgkin-lymphoma-immunotherapy-MOA-Reed-Sternberg-cell

Hodgkin Lymphoma Immunotherapy Animation

Biopharmaceutical client

axs-studio-medical-animation-antibody-drug-conjugate-endocytosis

Medical Animation: Immuno-Oncology ADC MOA

Biopharmaceutical client

axs-studio-medical-animation-oncology-immunotherapy-trojan

Medical Animation: Cancer Immunotherapy MOA

Biopharmaceutical client

axs-studio-medical-animation-osteoporosis-drug-MOA-01

Osteoporosis Animation: Sclerostin Inhibitor MOA

Biopharmaceutical client

axs-studio-medical-animation-ldl-recector-mab

Medical Animation: PCSK9 LDL Cholesterol Regulation MOA

Biopharmaceutical Client