Zoryve Mechanism-of-Action Animation
Created for Arcutis Biotherapeutics
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A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. It shows a psoriatic skin cube with Zoryve (roflumilast) cream on its surface. © 2022 Arcutis Biotherapeutics, Inc.
A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. This shot is a cross section view of roflumilast in a crystal emulsion butting up against the bilipid layers of the stratum corneum. Lipid bilayers of the emulsion and the ceramides in the skin are combining and roflumilast molecules are migrating from the emulsion into the skin. © 2022 Arcutis Biotherapeutics, Inc.
A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream that covers roflumilast’s mechanism of action. This shot shows a roflumilast molecule binding to PDE4 within the immune cell environment. © 2022 Arcutis Biotherapeutics, Inc.
A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. This shot is a view of immune cell and adjacent keratinocyte. © 2022 Arcutis Biotherapeutics, Inc.
The final screen from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. Final screen includes a 3d molecule of rolfumilast and summarizes advantages of Zoryve cream. © 2022 Arcutis Biotherapeutics, Inc.
The project
Targeting PDE4 with topical drugs has so far been unsuccessful due to the difficulty in crossing the epidermis without disrupting its barrier function. Arcutis solved this with a novel formulation of roflumilast that facilitates delivery to the cells that drive inflammation in psoriasis. To explain the innovative drug delivery process of HydroARQ Technology™, we worked with Arcutis scientists and devised a visual model of the emulsions that house roflumilast. A sectioned view of these emulsions and the lipid matrix between corneocytes enable us to clearly show in this mechanism-of-action animation how zoryve is able to diffuse passively between stratum corneum cells to reach its target.
Created for
Arcutis Biotherapeutics
