XL114 Mechanism of Action Animation

Created for Exelixis, Inc.
The project

This innovative mechanism-of-action (MOA)animation was created to educate HCPs on the role of CARD11-BCL10-MALT1 (CBM) in cancer and introduce the MOA of CBM inhibitor, XL114. We designed an animated schematic to explain how CBM bridges B-cell and T-cell receptor signaling to the NF-κB pathway. Components were modeled using protein structure data and mapped according to subcellular localization data. Multiple data were used to animate highly-complex CBM filament assembly.

Created for
Exelixis, Inc.