Plaque Psoriasis Drug MOA Animation
Created for Arcutis Biotherapeutics
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A shot from MOA animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. It shows a psoriatic skin cube with Zoryve (roflumilast) cream on its surface. © 2022 Arcutis Biotherapeutics, Inc.
A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. This shot is a cross section view of roflumilast in a crystal emulsion butting up against the bilipid layers of the stratum corneum. Lipid bilayers of the emulsion and the ceramides in the skin are combining and roflumilast molecules are migrating from the emulsion into the skin. © 2022 Arcutis Biotherapeutics, Inc.
A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream that covers roflumilast’s mechanism of action. This shot shows a roflumilast molecule binding to PDE4 within the immune cell environment. © 2022 Arcutis Biotherapeutics, Inc.
A shot from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. This shot is a view of immune cell and adjacent keratinocyte. © 2022 Arcutis Biotherapeutics, Inc.
The final screen from the commercial animation of Arcutis’ proprietary drug delivery technology ZORYVE (roflumilast) cream. Final screen includes a 3d molecule of rolfumilast and summarizes advantages of Zoryve cream. © 2022 Arcutis Biotherapeutics, Inc.
The project
In this plaque psoriasis drug MOA animation created for dermatologists, we present the innovative drug delivery mechanism of Zoryve. In dermatology, the role of the proinflammatory enzyme phosphodiesterase 4 (PDE4) in plaque psoriasis psoriasis is well established. However, inhibiting PDE4 with topical drugs has so far been unsuccessful. This is due to the difficulty in crossing the epidermis without disrupting its barrier function. Arcutis solved this with a novel formulation of roflumilast that facilitates delivery to the cells driving inflammation in plaque psoriasis. To explain this innovative drug delivery process, we worked with Arcutis scientists and devised a visual model of the emulsions that house roflumilast. We then sectioned these emulsions and the lipid matrix between corneocytes. Next, we animated the roflumilast molecules diffusing passively between stratum corneum cells to reach their target. In a second plaque psoriasis drug MOA animation (not shown), our medical animators depict how roflumilast acts to inhibit PDE4 activity.
Created for
Arcutis Biotherapeutics
![We’re excited to share that “Nanoparticle Delivery to a Solid Tumour” took home an Award of Excellence from the Association of Medical Illustrators (@amidotorg).
This 3D scientific animation was a collaboration between @axs_studio and the Integrated Nanotechnology and Biomedical Sciences (INBS) Laboratory, created to explain nanoparticle (NP) transport within a cancerous tumour microenvironment.
NPs have the potential to deliver therapeutic and diagnostic agents to tumours but a full understanding of their dynamics within the human body is essential to making the science a clinical reality for patients. That’s where INBS comes in.
INBS is a pioneer and global leader in nanotechnology, under the leadership of Prof. Warren Chan. Their active transport and retention (ATR) principle in Nature Nanotechnology (https://www.nature.com/articles/s41565-025-01877-5), challenged widely held beliefs about nanoparticle delivery to tumours.
AXS Studio collaborated with INBS scientists Matthew Nguyen and Jamie Wu on a concise scientific animation to explain this principle visually. Because scientific accuracy was essential, our medical animators consulted INBS’ extensive body of research data, including still and time-lapse micrographs, to accurately visualize the mechanisms governing NP tumor entry, retention, and exit. We also surveyed peer-reviewed sources on gross- and micro-anatomy to ensure accurate depiction of the tissue environments. The [finished video] is a captivating visualization of this groundbreaking INBS research.
The Association of Medical Illustrators is recognized as the premier global resource for promoting the power of visual media to advance scientific understanding, communication, education, and research.
#nanomedicine #medicalanimation #scientificanimation #cancer #science #healthcare #medicine #oncology #3danimation #axs3d #sciart](https://axs3d.com/wp-content/plugins/instagram-feed/img/placeholder.png)