Medical Animation: Cancer Small Molecule MOA
Created for Exelixis, Inc.
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XL114 mechanism of action (MOA) animation. XL114 is a small molecule inhibitor of the CARD11-BCL-MALT1 (CMB) complex, a key regulator of canonical NF-kappaB signaling downstream of B cell and T cell receptor activation. The precise MOA of XL114 is not known. © 2022 Exelixis, Inc.
XL114 mechanism of action (MOA) animation. XL114 is a small molecule inhibitor of the CARD11-BCL-MALT1 (CMB) complex, a key regulator of canonical NF-kappaB signaling downstream of B cell and T cell receptor activation. The precise MOA of XL114 is not known. © 2022 Exelixis, Inc.
XL114 mechanism of action (MOA) animation. XL114 is a small molecule inhibitor of the CARD11-BCL-MALT1 (CMB) complex, a key regulator of canonical NF-kappaB signaling downstream of B cell and T cell receptor activation. The precise MOA of XL114 is not known. © 2022 Exelixis, Inc.
XL114 mechanism of action (MOA) animation. XL114 is a small molecule inhibitor of the CARD11-BCL-MALT1 (CMB) complex, a key regulator of canonical NF-kappaB signaling downstream of B cell and T cell receptor activation. The precise MOA of XL114 is not known. © 2022 Exelixis, Inc.
The project
This innovative medical animation was created to educate HCPs on the role of CARD11-BCL10-MALT1 (CBM) in cancer and introduce the MOA of CBM inhibitor, XL114. We designed an animated schematic to explain how CBM bridges B-cell and T-cell receptor signaling to the NF-κB pathway. Components were modeled using protein structure data and mapped according to subcellular localization data. Multiple data were used to animate highly-complex CBM filament assembly. High-science visuals and rich cinematography combine to make this medical animation about a dense subject entertaining and informative.
Created for
Exelixis, Inc.
