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Scientific illustration: Certepetide Anticancer MOA

Created for Pharmaceutical client

The illustration has 4 panels depicting certepetide's mechanism of action. Certepetide is a 9 amino acide cyclic peptide that is Lisata's investigational agent. The first panel in the illustration depicts certepetide binding to an integrin on tumor/tumor vascular endothelium. The second panel shows proteolytic cleavage of certepetide. The third panel depicts the resulting CendR fragment binding to neuropilin-1 (NRP1). Panel 4 depicts the resulting tumor penetration (CendR pathway activation involving microvesicles that encapsulate co-administered anti-cancer drugs).

The project

Certepetide is a promising investigational drug targeting pancreatic cancer and other difficult-to-treat solid tumors. We developed this illustration to explain the complex certepetide MOA in 4 concise steps. The molecules were modeled to scale, using structural data, for a high degree of accuracy. Panel 4 shows how certepetide facilitates delivery of therapeutic agents via active transport through the tumor stroma to their targets. We designed the eye-catching color palette to integrate seamlessly with our client’s presentation materials and website.

Created for
Pharmaceutical client

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The illustration has 4 panels depicting certepetide's mechanism of action. Certepetide is a 9 amino acide cyclic peptide that is Lisata's investigational agent. The first panel in the illustration depicts certepetide binding to an integrin on tumor/tumor vascular endothelium. The second panel shows proteolytic cleavage of certepetide. The third panel depicts the resulting CendR fragment binding to neuropilin-1 (NRP1). Panel 4 depicts the resulting tumor penetration (CendR pathway activation involving microvesicles that encapsulate co-administered anti-cancer drugs).

Scientific illustration: Certepetide Anticancer MOA

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